A social ecological approach to identify the barriers and facilitators to COVID-19 vaccination acceptance: A scoping review

Background COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that has caused substantial impact on population health, healthcare, and social and economic systems around the world. Several vaccines have been developed to control the pandemic with varying effectiveness and safety profiles. One of the biggest obstacles to implementing successful vaccination programmes is vaccine hesitancy stemming from concerns about effectiveness and safety. This review aims to identify the factors influencing COVID-19 vaccine hesitancy and acceptance and to organize the factors using the social ecological framework. Methods We adopted the five-stage methodological framework developed by Arksey and O’Malley to guide this scoping review. Selection criteria was based on the PICo (Population, Phenomenon of interest and Context) framework. Factors associated with acceptance and hesitancy were grouped into the following: intrapersonal, interpersonal, institutional, community, and public policy factors using the social ecological framework. Results Fifty-one studies fulfilled this review’s inclusion criteria. Most studies were conducted in Europe and North America, followed by Asia and the Middle East. COVID-19 vaccine acceptance and hesitancy rates varied across countries. Some common demographic factors associated with hesitancy were younger age, being female, having lower than college education, and having a lower income level. Most of the barriers and facilitators to acceptance of the COVID-19 vaccines were intrapersonal factors, such as personal characteristics and preferences, concerns with COVID-19 vaccines, history/perception of general vaccination, and knowledge of COVID-19 and health. The remaining interpersonal, institution, community, and public policy factors were grouped into factors identified as barriers and facilitators. Conclusion Our review identified barriers and facilitators of vaccine acceptance and hesitancy and organised them using the social ecological framework. While some barriers and facilitators such as vaccine safety are universal, differentiated barriers might exist for different target groups, which need to be understood if they are to be addressed to maximize vaccine acceptance.


Introduction
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that has resulted in significant impact on the health of the world's population, with over 500 million confirmed cases and over 6.2 million deaths worldwide as of 3 rd June 2022 [1]. Other consequences include causing high levels of psychological distress as well as financial challenges for countries and their healthcare systems [2,3]. Hence, measures such as lockdowns, social distancing, and travel restrictions were imposed by many countries in an attempt to reduce the spread of infections. While such measures can help [4], they are not long-term solutions.
Vaccinations can have an integral role in restoring normalcy [5]. While several viable candidates have been developed, approved, and distributed, uptake of these vaccines can be hindered by vaccine hesitancy. A systematic review on COVID-19 vaccine acceptance rate found varying rates among the public and health care professionals in different countries [6]. The updated review also found variation of acceptance rates in different regions, with the Middle East/North Africa, Europe and central Asia, and Western/Central Africa having more COVID-19 vaccine hesitancy [7]. Common reasons cited for vaccine hesitancies are concerns with the safety or effectiveness of the vaccines [8][9][10][11][12][13].
On the other hand, a study using large-scale retrospective data around the world found that confidence in the importance of vaccines promoted vaccine uptake acceptance, whereas those in minority religious groups were more likely to be hesitant [14]. An individual's political affiliation is also among the contributing factors to COVID-19 vaccine hesitancy [15,16]. Clearly, there is a need to consider the human factor to ensure widespread acceptance of COVID-19 vaccines [5]. Recommendations from the World Health Organization (WHO) centered around the need to improve knowledge regarding vaccine safety and long-term effectiveness, ensure accessibility, and employing targeted interventions to address the concerns of specific populations [17].
To better understand the factors that posed as barriers or facilitated acceptance of COVID-19 vaccines in the general public adult population, we conducted a scoping review using the social ecological framework to segment the level of influences: Intrapersonal factors, interpersonal processes, institutional factors, community factors, and public policy [18,19]. As vaccine hesitancy is a complex issue that entails much more than one's attitude or behaviour [20,21], using the social ecological model could enhance understanding of external factors such as access to the vaccines that involve wider system-related factors. The identified factors would also be organized into barriers and facilitators to clarify if their influences on the acceptance or hesitancy of COVID-19 vaccination are mutually exclusive or are more complexly intertwined.
While there have been other scoping reviews conducted on the determinants to vaccine acceptance or hesitancy [11][12][13]22], our review focused on studies conducted on the general adult population that took place after the release of major COVID-19 vaccine clinical trial results to account for possible shifting reasons for vaccine acceptance and hesitancy. This review contributes by taking time sensitivity of the evolving barriers and facilitators into consideration [23].

Methods
We adopted the five-stage methodological framework developed by Arksey and O'Malley [24] with advancements to the framework proposed by Levac, Colquhoun and O'Brien [25] to guide this scoping review. In order to capture a variety of study types, the scoping review methodology was used. Quality assessments on the studies were not performed to allow for inclusion of more studies, as our purpose was to scope factors that could pose as barriers or facilitators to COVID-19 vaccine acceptance [24].

The research question
The research question was refined through reviewing the literature on acceptance of the COVID-19 vaccines: What are the barriers and facilitators that affect the acceptance of COVID-19 vaccines among adults in the general public?

Identifying relevant studies
The authors developed a search strategy with a medical librarian guided by the following key terms: COVID-19 or nCoV � or 2019nCoV or 19nCoV or COVID19 � or COVID or SARS--COV-2 or SARSCOV-2 or SARSCOV2 or "Severe Acute Respiratory Syndrome Coronavirus 2" or "Severe Acute Respiratory Syndrome Corona Virus 2" [26] and Vaccination Refusal or Anti-Vaccination Movement or Mass Vaccination or Vaccination Coverage (hesitancy or acceptance or preference or rejection or anti-vaccination or attitude or barrier or facilitator or intention). The search strategy was adapted for PubMed, Medline, Embase, PsycInfo, and CINAHL and conducted on April 14, 2021. S1 Table shows the full search strategy in the respective databases. Reference lists of review papers found were also searched.

Study selection
Selection criteria was based on the PICo (Population, Phenomenon of interest and Context) framework [27]. Table 1 presents details of the criteria. Time frame on the data collection (study) period rather than publication date was imposed for two reasons. Firstly, a recent scoping review reported on attitudes towards COVID-19 vaccination using the social-ecological model had included studies conducted before September 2020 [22]. Secondly, as people might change their minds with new information, we wanted to capture factors and perspectives that were more aligned with the actual COVID-19 vaccine situation after publication of the Pfizer and Moderna phase I/II trials data in the summer of 2020. The title/abstract screening were conducted by three reviewers (BT, PL, JG) independently, with one main reviewer (BT) going through all titles and abstracts, while PL and JG shared the task as second reviewers. Any disagreements between two reviewers were discussed and resolved by the third reviewer (BT, PL, JG). During the full text review, each full text was again screened by two reviewers (combination of BT/PL, BT/JG, PL/JG) and disagreements were resolved by the third. As reported by Levac and colleagues [25], the screening process was iterative in order to refine the inclusion criteria. To calibrate our understanding during the screening process, disagreements were reviewed on a regular basis.

Charting the data
The data extraction form was developed and pilot-tested before the start of the extraction phase. The extraction fields included publication details, study design and population, rates of COVID-19 vaccine acceptance/hesitancy, and reported factors influencing COVID-19 vaccine acceptance and hesitancy. Similar to studies that examined such factors using barriers and facilitators [28,29], we defined factors associated with acceptance as facilitators and factors that deterred acceptance of the vaccination as barriers. These factors were then categorized using the social ecological framework [19] into intrapersonal factors, interpersonal processes, institutional/organizational factors, community factors, and public policy.
Intrapersonal factors include one's knowledge, attitudes, behavior, self-concepts, and skills, whereas interpersonal factors are the influences from formal and informal social networks [19]. Institutional factors describe "social institutions and organization characteristics, and formal (and informal) rules and regulations for operations" [19] that impact people's acceptance of the COVID-19 vaccines and vaccination. Community factors refer to relationships among organizations and groups with boundaries defined by geographical and political terms, whereas public policy refers to policies or programs that promote or deter certain behaviors [19]. To better conceptualize each level in the social ecological model, sub-categories defined in other vaccine studies using the framework were adapted to guide allocation of the extracted factors [30,31]. To ensure objectivity, data from each included article was extracted by one reviewer independently (BT, JG, or PL) and 20% of the extracted data were cross-checked by a second reviewer (BT, JG, or PL). The screening and data extraction were conducted in Covidence systematic review software [32]. S3 and S4 Tables show the data extracted and the excluded full text with reasons respectively.

Collation, summarizing, and reporting the results
The results were collated and summarized descriptively by the three reviewers (BT, JG, PL). The factors and themes (when necessary) identified were classified under barriers or facilitators in the social ecological framework. These were shared and discussed with the remaining research team before finalization. Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review (PRISMAScR) was used to report this scoping review (see S5 Table) [33].

Results
A total of 1066 unique citations were found using our search strategy. After the title/abstract screening, 233 citations were included for full text screening, of which 51 articles fulfilled the inclusion criteria for synthesis. Most of these articles were published in 2021(n = 46, 90%), whereas the rest were published in 2020. Fig 1 shows the PRISMA flow diagram of the screening process for the review [34].

Acceptance/Hesitancy rate
Thirty-seven of the 51 studies reported COVID-19 vaccine acceptance and/or hesitancy rates. Most of these studies assessed one's willingness or intentions to take the COVID-19 vaccines when available, using Likert-type scales, instead of validated scales such as the Vaccination Attitudes Examination (VAX) Scale [42,43]. One study measured trust in the vaccines [44]. For the purpose of our study, the hesitancy rates included those who: (a) reported unwillingness to accept the vaccination, (b) were strongly hesitant, or (c) reported being very unlikely to accept COVID-19 vaccination.
Global acceptance rates ranged from 13.1-91%, and hesitancy rates ranged from 7-86.6%. Studies from Spain (77.6%), Germany (78.2%), China (81.3-88.6%), and India (83.6%) reported acceptance rates over 70%. Some studies in Italy [45], UK [35,40,46], and USA [47] also reported acceptance rates over 70%. On the other hand, studies from Hong Kong [48] and several middle Eastern countries [36] reported acceptance rates of below 30%. Acceptance and/or hesitancy rates could not be determined in 13 studies, as they were experimental studies or social media studies that measured positive and negative sentiments towards the vaccines, or were studies that presented only stratified results (e.g., gender, ethnic). Table 3 summarizes the acceptance and hesitancy rates by country.

Barriers and facilitators using social ecological framework
Socio-demographic determinants. In general, most studies found that lower age, being female, having lower than college education, having a lower income level, and having or living with school age children were commonly cited determinants of vaccine hesitancy and rejection. A minority of the studies found opposite trends. For example, two studies found that males were more hesitant than females [49,50], whereas one study found that higher education was a barrier [48] and another where having the least education was a facilitator [51]. With regards to age, a positive trend of COVID-19 vaccine acceptance among older adults above 60 to 70 were reported in several studies [9,10,38,48,[52][53][54]. However, one study conducted in Qatar found that being older than 65 was a significant factor in vaccine hesitancy, compared to the younger participants surveyed [43]. Interestingly, a discrete choice experiment study found that those aged 55 and above were significantly more likely to reject a vaccine with 50% protection, while being significantly more likely to accept a vaccine with 90% protection, when compared to the younger participants [40]. In addition, a few studies that identified ethnic minority as a determinant of vaccine hesitancy were conducted in the UK and USA [10,35,46,47,52,[55][56][57]. Although few studies measured political leanings, their results were consistent, where those identifying with conservative ideology tended to be more hesitant [44,58], compared to those identifying with liberal/ democratic political ideology [44,52,58,59]. Having comorbidities could either be a barrier, when one has compromised immunity or conditions in which the vaccine was not recommended [44,60], or a facilitator [10, 36, 41, 48-50, 53, 54, 61, 62] where one identifies as being vulnerable to the severe effects of COVID-19. Likewise, perceived fair or good health could be a barrier [9,52] or perceived reasonable health as a facilitator [61] to one's willingness to be vaccinated. Current smokers [65,72], and those who have psychological distress, were less likely to accept the vaccine [56]. Table 4 shows a full list of the social demographic factors identified.
Intrapersonal factors. As there were many identified factors in this category, they were further categorized into broader themes, namely: Individual characteristics and preferences, concerns with COVID-19 vaccines, history/experience of vaccination, and knowledge/perception of COVID-19 and health-related information. Individual characteristics and preferences. Those who have had COVID-19 infections and believed that they have acquired immunity [55,60], and those who preferred to acquire immunity naturally, were less likely to accept the vaccination [37, 38, 42-44, 50, 65, 72]. Those who experienced negative emotions (felt agitated, sad, or anxious) or adhered less with health measures and guidelines, such as wearing a mask and safe distancing, or not having been quarantined, were also less likely to accept the vaccine [42,46,49,61]. Having a strong perception of one's autonomy [71] and not believing that being vaccinated was one's civic duty as a citizen [47] were barriers to accepting the vaccines as well. On the other hand, the belief that getting vaccinated protected others or was one's social responsibility was associated with acceptance towards COVID-19 vaccination [29, 35, 47, 50-53, 70, 73, 74]. The desire to return to normalcy also facilitated acceptance of the vaccines [35,54,74,75]. Lastly, one study conducted in Saudi Arabia found that those believing in mandatory vaccinations were more likely to accept the COVID-19 vaccination [69].
Those with the least education [51].
Have chronic conditions/compromised immune that the vaccine was not recommended [44,60].
Interpersonal factors. Influence from those who were vaccinated, influence from those infected with COVID-19, and normative influences from family and friends were three factors found that impact one's perception and attitude toward COVID-19 vaccination acceptance. Knowing someone with a serious vaccine reaction [52] or not knowing anyone close who was affected by COVID-19 [64] were barriers to one's acceptance, whilst knowing someone who was infected [66], or knowing people who had been or intended to get vaccinated [29,48,54],

Factors
Associated with hesitancy Associated with acceptance
Perceived health status as reasonable compared to good or very good [61]. To achieve peace of mind [71]. Lower self-rated overall health [65]. Under/over-weight [65].
Willing to take risk Not willing to be among the first to take the vaccine [38] Willing to take risk [68].
No longer need preventive measures after vaccination [54].
Willing for others around them to be vaccinated N.A. Willing for others around them to be vaccinated [38].
(Continued ) facilitated acceptance. In addition, trusting information or valuing opinions of family, friends, and acquaintances could either be a barrier [37] or a facilitator [38,71], depending on their own views on hesitancy or acceptance. For example, one study found that the opinion of family and friends was significantly correlated with participants' willingness to take a COVID-19 vaccine [38]. Institutional/Organizational factors. Four institutional/organizational factors were found to influence one's acceptance of the vaccine: (a) Trust/confidence in governments/ authorities, (b) trust/confidence in science, and/or healthcare/healthcare personnel, (c) development of COVID-19 vaccines, and (d) impact of social media vs. legacy media (e.g., newspapers, radio, television). Studies that measured social media responses were included in this category.
Low trust or mistrust toward the government and health authorities, such as WHO and the Centres for Disease Control and Prevention (CDC), could pose as a barrier to one's acceptance of the COVID-19 vaccination [37,40,43,44,47,52,55,61,63,66,74], whereas high trust and confidence in the government and health authorities promoted acceptance of the vaccines [10,37,44,48,52]. Similarly, low trust or mistrust of the pharmaceutical industry and healthcare providers would make one less likely to accept the COVID-19 vaccines [44,46,47,52,61,66,76,77], including those who were concerned with profiteering by the pharmaceutical companies [29,42,72]. A lack of recommendation by a doctor has been cited as a reason for not intending to take the COVID-19 vaccine [55], whereas having a recommendation from a doctor influenced vaccine acceptance [67,78].
In addition, the speedy development of the vaccines [29,55,60,76,77], the manufacturing country [48,77,81], and the perceived lack of information or clear data (e.g., inconsistent/ contradictory/delays and trial pauses) contributed to people's hesitancy [9,60,61,79]. While trusting alternative sources of information, and exposure to coverage on WhatsApp, blogs, and social media were more likely to increase one's hesitancy toward the vaccines [37,40,57], one study found that frequent exposure to positive social media messages facilitated one's acceptance [48]. As expected, those who trusted official sources of information and legacy media were less likely to be hesitant toward the vaccines [37,44,57,75,79]. A point to note is that those who thought that the media over-reported on the side effects of the vaccines facilitated their acceptance of the vaccines [41].
Community factor and public policy. Low magnitude of community spread (e.g., number of confirmed or suspected cases in the county) could pose as a barrier to vaccine acceptance [78]. In addition, rate of community vaccination could either result in low perceived risk, which would be a barrier [50] or a facilitator, if that nudged one into getting vaccinated [67]. Meanwhile, the choice of the vaccination venue could either be a barrier [40,49] or a facilitator [40] to one's willingness to be vaccinated, depending on if their preferences were met. Cost of the vaccine [39,78] or associated cost with the vaccines [55] could also be a barrier to some, especially for those without health insurance [55].
The effects of politics have spilled over to influence people on their hesitancy or acceptance of the vaccines. Those who believed that political pressure had influenced the development speed of the vaccine were more likely to be hesitant toward accepting the vaccines, and

Themes Factors Barriers Facilitator
Facts Vs fake news Exposure to misinformation [70]. Exposure to facts [70].

Discussion
COVID-19 vaccine acceptance and uptake are important factors that could help curb the spread and severity of the disease. Our review distils the factors reported around the world Table 6. Other factors (interpersonal, institutional, community, public policy).

Factors Barriers Facilitators
Influence from those who were vaccinated Knowing someone with a serious vaccine reaction [52]. People around me (including role models) have been vaccinated or intend to get vaccinated [29,48,54].

Normative influences: Families and friends
Trusting information from friends and acquaintances (non-Healthcare profession) [37].
Valuing opinions of family/friends or those in this group who share the same views/beliefs [38,71].
NA Frequency of socializing prior to the pandemic [63].

Impact of social media Vs legacy media
Coverage on WhatsApp, blogs and social media; Trust alternative sources of information [37,40,57].
Frequency of exposure to positive social media messages [48].

Magnitude of community spread
Number of confirmed or suspected cases in the community [78]. N.A.
into various levels in the social ecological model revealing the environmental influencing factors at play [19,83], upon which targeted interventions or policies could be considered. By organizing the factors into barriers and facilitators, the comparison highlighted that the same factor could either promote or deter vaccine acceptance.
In consensus with other reviews, demographic factors such as being female, being younger, having lower education, or having a low income contributed to COVID 19 vaccine hesitancy [11-13, 22, 84]. Similar to the findings by Al-Jayyousi et al [22], our results show that most factors identified are related to intrapersonal level on one's knowledge, attitudes, behavior, selfconcepts, and skills. These factors are a culmination of one's experiences and interactions with the environment, which would be difficult to influence quickly. For example, pre-existing factors that impact vaccine acceptance or hesitancy include history and perception of general vaccinations, knowledge of COVID-19 and health-related information, belief in conspiracy theories, as well as personal characteristics and preferences [22].
A major intrapersonal factor that is unique to COVID-19 vaccines is the concern regarding their effectiveness and potential side effects, including their long-term safety, which were also identified in other reviews [11,12,22,76]. These are valid concerns given the accelerated rate of the COVID-19 vaccine development and the lack of long-term safety data [85,86]. Although many benefitted, and are still benefitting from this unprecedented speed in the history of vaccine development, others cited it as a concern that led to their hesitancy [29,55,60,76,77]. A recent multi-country survey that tested acceptance of four hypothetical COVID-19 vaccines with varying efficacy and safety profiles found that higher efficacy and lower risks increased the acceptance level among study participants [87]. An interesting point to note from this study was that those believing that new vaccines are riskier than older vaccines were less likely to accept any of the new hypothetical vaccines [87].
Besides intrapersonal factors, common factors found in COVID-19 vaccine acceptance or hesitancy can be broadly summarized into trust in authorities (government/health care including pharmaceutical) and trust in legacy media versus social media [11,12,22,76]. In our review, such factors were categorised under institutional factors. Citing concerns on effectiveness and safety of a vaccine imply some level of doubt in the authorities [88]. Trust and confidence in any authorities stem from historic and existing systems that could not be addressed instantly but would affect people's attitude towards the current recommended vaccines [21,88,89]. Understanding weaknesses in the system and investing in better healthcare structure would be longer-range goals that could ultimately address people's trust issues [21]. For more immediate results, communicating consistent information on efficacy and safety of the COVID-19 vaccines could impact people's acceptance of the vaccines [87], which might help combat misinformation in the media and social media.
While influence from family and friends was briefly mentioned in the other reviews, our findings suggested that interpersonal level of influence could play a substantial role in swaying one toward or away from acceptance of the COVID-19 vaccines. One would be more hesitant if they knew someone who had a serious adverse reaction from the vaccine [52] or did not know someone close that was affected by the disease [64], whereas knowing people who were vaccinated, especially one's role model [29,48,54], or knowing someone infected with COVID-19 [66], would facilitate vaccine acceptance. However, it could also be the case that individuals tend to socialise with others like them (i.e., someone pro-vaccination would likely socialise with other pro-vaccination individuals). Two studies found that valuing opinions of family or friends who share the same views/beliefs facilitated COVID-19 vaccine acceptance [38,71]. Hence, the exact nature of the role played by family and friends in vaccination decisions should be explored further in future research so that policies or programs that target those who are hesitant could consider extending beyond that individual.
As demonstrated in the above example, our findings highlighted that even though some factors seemed to present a clearer direction for intervention or policy, others were more contextdependent and not clearly a barrier or facilitator. For instance, having comorbidities or belonging to a high-risk group could be a positive factor that motivates people to be vaccinated [10, 36, 41, 48-50, 53, 54, 61, 62]. Conversely, the same factor presented as a barrier for others who were likely concerned with how the vaccine would impact their medical conditions or health [44,60]. However, this could be due to an earlier advisory which cautioned against vaccination for those with certain medical conditions, which has since changed [90,91]. Perceived good health could also pose either as a barrier [9,52] or a facilitator [61] to one's willingness to be vaccinated. In short, having contextual information on the target population will be crucial to understand factors that pose as barriers and facilitators.

Implications
Although organizing the factors by respective levels of influence in the social ecological framework provided some distinctions that could inform areas for potential interventions or policies, they are still very much intertwined and pose more questions, such as the exact nature of the role played by family and friends in vaccination decisions. Further research on this relationship might make identifying effective strategies to overcome barriers easier.
Consequently, the need to understand the context, especially of the barriers, should be emphasized, since the same factor could be a facilitator to some while a barrier to others. Structural barriers [92] such as the community and public policy factors affect access and could impact people's acceptance to be vaccinated. Attitudinal barriers [92] such as the factors identified in the intrapersonal, interpersonal, and institutional/organizational levels played a major role in influencing one's acceptance or hesitancy but are more complex to address. Some of these attitudinal barriers could stem from institutional or policy level gaps that would only be known if time and effort were taken to understand them [21]. This could be achieved through engaging targeted subgroups, groups, or communities through partnership [92], such as through dialogues.
In addition, COVID-19 is the first pandemic in the 21 st century with unprecedented worldwide aftermath, as well as having on-going impacts on population health and economics [93]. As parts of the world are beginning to recover from the aftermath of the initial COVID-19 infection, COVID-19 has been shown to be a moving target that would continue to influence people's views and acceptance of the vaccines. With scientists warning of more of such infectious diseases in the future [94,95], it might be important to study the current dynamic response of people's acceptance and hesitancy toward COVID-19 vaccines during different periods of the pandemic. For example, the findings from this review provide some insights into the general population's views on accepting a newly developed vaccine after results of the trials confirmed they were effective and safe. Insights gathered could serve as a guide to future response plans for new infectious disease outbreaks (e.g., by pre-emptively addressing concerns before commencing a nationwide vaccination effort).
Lastly, COVID-19 vaccine rollout prioritized those most at risk, such as healthcare workers and older adults; the latter are the most vulnerable to severe infection and death. As people's needs and situations are heterogeneous, a customized approach to different segments of the population has proven to be both pragmatic and essential. Seeking to understand which factors pose as barriers or facilitators, and for which populations, could help inform context-relevant policies or programs.

Limitations
Our findings have several limitations. It is possible that some studies have been missed by our search strategy, due to adopting a more general search strategy. Summarizing the heterogeneous studies was challenging, especially on what vaccine hesitancy entails, which was not explored in depth due to the complexity of the ongoing discussion surrounding the term vaccine hesitancy; thus, we determined it to be beyond the scope of our study. For instance, most studies developed their own surveys to measure vaccine acceptance or hesitancy and the lack of methodological equivalence could cause differences in findings. In addition, we have several inherent limitations when using the social-ecological framework, as classifying factors into the five categories were subjective. Although we minimised the subjectivity through defining sub-categories of each factor in the framework a priori, and performed cross checks to calibrate our understanding and agreement, we acknowledge that subjectivity may not have been completely eliminated.
While there are limitations in using barriers and facilitators, due to the overlapping of factors (as well as not clearly addressing the interrelatedness of those factors) [23], the social-ecological framework has helped to frame those realms, which provided some clarity and insights. The above limitations notwithstanding, our review has identified important barriers and facilitators of vaccine acceptance and hesitancy.

Conclusion
Our review has identified barriers and facilitators of vaccine acceptance and hesitancy and organised them using the social ecological framework. These factors are context-, population-, and even sub-population-dependent, which could present either as barriers or facilitators. It also shows that factors associated with COVID-19 vaccine acceptance and hesitancy could stem from different levels of influence that are intertwined. Our findings present a general scope of barriers or facilitators that should be considered when developing programs or policies to promote acceptance and uptake of the COVID-19 vaccines, while highlighting the need to also consider the varying contexts experienced by different population.
Supporting information S1  Table. Preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) checklist. (PDF)